Discoloured urine after Leptospirosis Vaccine in dogs

The FDA has received 41 reports of discoloured urine in dogs after Leptospirosis Vaccine. That is 0.5% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

41Reports

73%Marked serious

0.0%Recovered

20%Died or euthanised

19 daysTypical onset

How soon it started

Same day

6 17%

1–2 days

3 8.3%

3–7 days

5 14%

1–4 weeks

10 28%

Over a month

12 33%

How the animals did

Still unwell when reported

24 59%

Died

2 4.9%

Euthanised

6 15%

Not known

9 22%

Problems reported at the same time

28 68%

19 46%

19 46%

18 44%

16 39%

10 24%

8 20%

8 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause discoloured urine in dogs?: 41 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 19 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Discoloured urine with similar medicines

Discoloured urine after Rabies Vaccine 48 reports · 0.5% of its reports
Discoloured urine after Bordetella Vaccine 37 reports · 0.4% of its reports
Discoloured urine after Distemper-parvo Vaccine 22 reports · 0.3% of its reports

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with discoloured urine