Underdose after Ilunocitinib (Zenrelia) in dogs

32 reports to the FDA describe underdose in dogs given Ilunocitinib. That is 1.5% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

32Reports

9.4%Marked serious

22%Recovered

3.1%Died or euthanised

17 daysTypical onset

How soon it started

Same day

4 13%

1–2 days

3 10%

3–7 days

4 13%

1–4 weeks

6 20%

Over a month

13 43%

How the animals did

Recovered

7 22%

Still unwell when reported

9 28%

Euthanised

1 3.1%

Not known

15 47%

Problems reported at the same time

Didn't work as expected

9 28%

5 16%

4 13%

3 9.4%

2 6.3%

2 6.3%

Skin rash or irritation

2 6.3%

Fever

2 6.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause underdose in dogs?: 32 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 17 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Underdose with similar medicines

Underdose after Oclacitinib (Apoquel) 575 reports · 2.0% of its reports
Underdose after Cyclosporine (Atopica) 134 reports · 0.9% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with underdose