Underdose after Cyclosporine (Atopica) in dogs

The FDA has received 134 reports of underdose in dogs after Cyclosporine. That is 0.9% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

134Reports

38%Marked serious

26%Recovered

2.2%Died or euthanised

30 daysTypical onset

How soon it started

Same day

10 16%

1–2 days

2 3.1%

3–7 days

5 7.8%

1–4 weeks

16 25%

Over a month

31 48%

How the animals did

Recovered

33 25%

Recovered with lasting effects

2 1.5%

Still unwell when reported

38 28%

Euthanised

3 2.2%

Not known

58 43%

Problems reported at the same time

Didn't work as expected

57 43%

34 25%

23 17%

15 11%

15 11%

14 10%

7 5.2%

Incorrect dose administered

7 5.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause underdose in dogs?: 134 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 30 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Underdose with similar medicines

Underdose after Oclacitinib (Apoquel) 575 reports · 2.0% of its reports
Underdose after Ilunocitinib (Zenrelia) 32 reports · 1.5% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with underdose