Liver problems after Hydromorphone in dogs

The FDA has received 146 reports of liver problems in dogs after Hydromorphone. That is 14% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

146Reports
79%Marked serious
16%Recovered
40%Died or euthanised
5 daysTypical onset
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How soon it started

Same day
18 14%
1–2 days
30 23%
3–7 days
29 22%
1–4 weeks
36 27%
Over a month
19 14%

How the animals did

Recovered
24 16%
Still unwell when reported
49 34%
Died
15 10%
Euthanised
43 29%
Not known
15 10%

Problems reported at the same time

Age of the animals

Under 1 year
3
1–3 years
39
4–7 years
49
8–11 years
44
12+ years
11

About this medicine

Type: medicine.

Questions owners ask

Can Hydromorphone cause liver problems in dogs?
146 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 5 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Hydromorphone in dogs · Medicines most reported with liver problems