Leucocytosis after Grapiprant (Galliprant) in dogs

151 reports to the FDA describe leucocytosis in dogs given Grapiprant. That is 1.7% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

151Reports
79%Marked serious
7.9%Recovered
27%Died or euthanised
15 daysTypical onset
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How soon it started

Same day
12 11%
1–2 days
18 16%
3–7 days
18 16%
1–4 weeks
16 14%
Over a month
48 43%

How the animals did

Recovered
12 7.9%
Still unwell when reported
65 43%
Died
4 2.6%
Euthanised
37 25%
Not known
33 22%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
3
4–7 years
14
8–11 years
59
12+ years
73

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause leucocytosis in dogs?
151 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 15 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with leucocytosis