Diarrhea after Grapiprant (Galliprant) in dogs

The FDA has received 1,724 reports of diarrhea in dogs after Grapiprant. That is 20% of all reports for this medicine, compared with 8.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,724Reports
31%Marked serious
32%Recovered
10%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
283 20%
1–2 days
258 18%
3–7 days
219 16%
1–4 weeks
217 15%
Over a month
426 30%

How the animals did

Recovered
549 32%
Recovered with lasting effects
3 0.2%
Still unwell when reported
580 34%
Died
41 2.4%
Euthanised
135 7.8%
Not known
416 24%

Problems reported at the same time

Age of the animals

Under 1 year
20
1–3 years
50
4–7 years
162
8–11 years
560
12+ years
805

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause diarrhea in dogs?
1,724 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with diarrhea