Loss of appetite after Grapiprant (Galliprant) in dogs

The FDA has received 1,595 reports of loss of appetite in dogs after Grapiprant. That is 18% of all reports for this medicine, compared with 8.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,595Reports
50%Marked serious
21%Recovered
20%Died or euthanised
14 daysTypical onset
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How soon it started

Same day
165 13%
1–2 days
175 14%
3–7 days
196 16%
1–4 weeks
215 17%
Over a month
501 40%

How the animals did

Recovered
327 21%
Recovered with lasting effects
1 0.1%
Still unwell when reported
630 39%
Died
57 3.6%
Euthanised
263 16%
Not known
317 20%

Problems reported at the same time

Age of the animals

Under 1 year
14
1–3 years
37
4–7 years
134
8–11 years
587
12+ years
789

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause loss of appetite in dogs?
1,595 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 14 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with loss of appetite