Breathing problems after Grapiprant (Galliprant) in dogs

The FDA has received 504 reports of breathing problems in dogs after Grapiprant. That is 5.7% of all reports for this medicine, compared with 2.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

504Reports
63%Marked serious
21%Recovered
28%Died or euthanised
19 daysTypical onset
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How soon it started

Same day
74 19%
1–2 days
38 10%
3–7 days
31 8.2%
1–4 weeks
70 18%
Over a month
167 44%

How the animals did

Recovered
100 20%
Recovered with lasting effects
4 0.8%
Still unwell when reported
162 32%
Died
46 9.1%
Euthanised
97 19%
Not known
95 19%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
13
4–7 years
43
8–11 years
180
12+ years
259

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause breathing problems in dogs?
504 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 19 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with breathing problems