Restlessness or agitation after Grapiprant (Galliprant) in dogs

203 reports to the FDA describe restlessness or agitation in dogs given Grapiprant. That is 2.3% of all reports for this medicine, compared with 1.6% across reports for all dog medicines.

203Reports
43%Marked serious
23%Recovered
15%Died or euthanised
5 daysTypical onset
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How soon it started

Same day
43 27%
1–2 days
23 14%
3–7 days
18 11%
1–4 weeks
22 14%
Over a month
54 34%

How the animals did

Recovered
45 22%
Recovered with lasting effects
1 0.5%
Still unwell when reported
77 38%
Died
7 3.4%
Euthanised
23 11%
Not known
50 25%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
6
4–7 years
18
8–11 years
57
12+ years
118

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause restlessness or agitation in dogs?
203 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 5 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with restlessness or agitation