Behaviour change after Grapiprant (Galliprant) in dogs

361 reports to the FDA describe behaviour change in dogs given Grapiprant. That is 4.1% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

361Reports
39%Marked serious
25%Recovered
14%Died or euthanised
5 daysTypical onset
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How soon it started

Same day
70 25%
1–2 days
45 16%
3–7 days
37 13%
1–4 weeks
34 12%
Over a month
92 33%

How the animals did

Recovered
88 24%
Recovered with lasting effects
2 0.6%
Still unwell when reported
124 34%
Died
12 3.3%
Euthanised
39 11%
Not known
96 27%

Problems reported at the same time

Age of the animals

Under 1 year
5
1–3 years
12
4–7 years
32
8–11 years
125
12+ years
166

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause behaviour change in dogs?
361 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 5 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with behaviour change