Weakness after Grapiprant (Galliprant) in dogs

480 reports to the FDA describe weakness in dogs given Grapiprant. That is 5.5% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

480Reports
64%Marked serious
12%Recovered
31%Died or euthanised
24 daysTypical onset
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How soon it started

Same day
60 15%
1–2 days
43 11%
3–7 days
34 8.6%
1–4 weeks
75 19%
Over a month
182 46%

How the animals did

Recovered
56 12%
Recovered with lasting effects
2 0.4%
Still unwell when reported
206 43%
Died
25 5.2%
Euthanised
124 26%
Not known
67 14%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
5
4–7 years
21
8–11 years
158
12+ years
290

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause weakness in dogs?
480 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 24 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weakness with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with weakness