Inappropriate urination after Grapiprant (Galliprant) in dogs

The FDA has received 153 reports of inappropriate urination in dogs after Grapiprant. That is 1.7% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

153Reports
50%Marked serious
24%Recovered
19%Died or euthanised
24 daysTypical onset
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How soon it started

Same day
17 15%
1–2 days
16 15%
3–7 days
7 6.4%
1–4 weeks
22 20%
Over a month
48 44%

How the animals did

Recovered
37 24%
Still unwell when reported
70 46%
Died
3 2.0%
Euthanised
26 17%
Not known
17 11%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
13
8–11 years
36
12+ years
101

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause inappropriate urination in dogs?
153 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 24 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Inappropriate urination with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with inappropriate urination