Excessive urination after Grapiprant (Galliprant) in dogs

The FDA has received 220 reports of excessive urination in dogs after Grapiprant. That is 2.5% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

220Reports
44%Marked serious
15%Recovered
8.6%Died or euthanised
31 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
23 14%
1–2 days
17 10%
3–7 days
10 6.1%
1–4 weeks
32 19%
Over a month
83 50%

How the animals did

Recovered
29 13%
Recovered with lasting effects
3 1.4%
Still unwell when reported
131 60%
Euthanised
19 8.6%
Not known
38 17%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
2
4–7 years
10
8–11 years
85
12+ years
119

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause excessive urination in dogs?
220 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive urination with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with excessive urination