Excessive thirst after Grapiprant (Galliprant) in dogs

The FDA has received 284 reports of excessive thirst in dogs after Grapiprant. That is 3.2% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

284Reports
46%Marked serious
14%Recovered
14%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
38 18%
1–2 days
19 9.0%
3–7 days
18 8.5%
1–4 weeks
29 14%
Over a month
108 51%

How the animals did

Recovered
36 13%
Recovered with lasting effects
3 1.1%
Still unwell when reported
148 52%
Died
2 0.7%
Euthanised
38 13%
Not known
57 20%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
3
4–7 years
14
8–11 years
105
12+ years
151

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause excessive thirst in dogs?
284 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive thirst with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with excessive thirst