Urinary incontinence after Grapiprant (Galliprant) in dogs

195 reports to the FDA describe urinary incontinence in dogs given Grapiprant. That is 2.2% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

195Reports
53%Marked serious
9.7%Recovered
19%Died or euthanised
36 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
25 17%
1–2 days
9 6.2%
3–7 days
11 7.5%
1–4 weeks
16 11%
Over a month
85 58%

How the animals did

Recovered
19 9.7%
Still unwell when reported
117 60%
Died
5 2.6%
Euthanised
33 17%
Not known
21 11%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
4
4–7 years
13
8–11 years
62
12+ years
112

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause urinary incontinence in dogs?
195 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 36 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary incontinence with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with urinary incontinence