Urinary tract infection after Grapiprant (Galliprant) in dogs

The FDA has received 179 reports of urinary tract infection in dogs after Grapiprant. That is 2.0% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

179Reports

61%Marked serious

11%Recovered

11%Died or euthanised

45 daysTypical onset

How soon it started

Same day

13 10%

1–2 days

8 6.2%

3–7 days

6 4.6%

1–4 weeks

22 17%

Over a month

81 62%

How the animals did

Recovered

20 11%

Still unwell when reported

101 56%

Died

4 2.2%

Euthanised

15 8.4%

Not known

39 22%

Problems reported at the same time

45 25%

40 22%

37 21%

35 20%

Didn't work as expected

29 16%

Inappropriate urination

27 15%

Diarrhea

25 14%

Lethargy

24 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

110

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause urinary tract infection in dogs?: 179 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 45 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary tract infection with similar medicines

Urinary tract infection after Carprofen (Rimadyl) 468 reports · 1.0% of its reports
Urinary tract infection after Deracoxib (Deramaxx) 123 reports · 1.1% of its reports
Urinary tract infection after Meloxicam (Metacam) 79 reports · 1.0% of its reports
Urinary tract infection after Firocoxib (Previcox) 58 reports · 0.7% of its reports

All reported side effects of Grapiprant in dogs · Medicines most reported with urinary tract infection