Elevated gamma-glutamyl transferase (ggt) after Enalapril in dogs

30 reports to the FDA describe elevated gamma-glutamyl transferase (ggt) in dogs given Enalapril. That is 1.8% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

30Reports
67%Marked serious
6.7%Recovered
20%Died or euthanised
73 daysTypical onset
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How soon it started

Same day
2 12%
1–2 days
0 0.0%
3–7 days
0 0.0%
1–4 weeks
3 18%
Over a month
12 71%

How the animals did

Recovered
1 3.3%
Recovered with lasting effects
1 3.3%
Still unwell when reported
10 33%
Died
3 10%
Euthanised
3 10%
Not known
12 40%

Problems reported at the same time

Liver problems
28 93%
Loss of appetite
12 40%
Lethargy
11 37%
Kidney problems
9 30%
Decreased urine concentration
8 27%
Elevated cholesterol (total)
8 27%
Hyperkalaemia
7 23%
Weight loss
7 23%

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
1
8–11 years
10
12+ years
15

About this medicine

Type: medicine.

Questions owners ask

Can Enalapril cause elevated gamma-glutamyl transferase (ggt) in dogs?
30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 73 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated gamma-glutamyl transferase (ggt) with similar medicines

All reported side effects of Enalapril in dogs · Medicines most reported with elevated gamma-glutamyl transferase (ggt)