Eosinophilia after Doxycycline in dogs

The FDA has received 32 reports of eosinophilia in dogs after Doxycycline. That is 0.8% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

32Reports

72%Marked serious

16%Recovered

19%Died or euthanised

62 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

0 0.0%

3–7 days

0 0.0%

1–4 weeks

4 29%

Over a month

10 71%

How the animals did

Recovered

5 16%

Still unwell when reported

12 38%

Died

2 6.3%

Euthanised

4 13%

Not known

9 28%

Problems reported at the same time

15 47%

15 47%

15 47%

14 44%

14 44%

14 44%

Abnormal radiograph finding

13 41%

Blood problems

12 38%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause eosinophilia in dogs?: 32 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 62 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eosinophilia with similar medicines

Eosinophilia after Amoxicillin + Clavulanate (Clavamox) 32 reports · 0.6% of its reports
Eosinophilia after Metronidazole 22 reports · 0.7% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with eosinophilia