Eosinophilia after Amoxicillin + Clavulanate (Clavamox) in dogs

32 reports to the FDA describe eosinophilia in dogs given Amoxicillin + Clavulanate. That is 0.6% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

32Reports

72%Marked serious

16%Recovered

25%Died or euthanised

12 daysTypical onset

How soon it started

Same day

4 16%

1–2 days

4 16%

3–7 days

4 16%

1–4 weeks

9 36%

Over a month

4 16%

How the animals did

Recovered

5 16%

Still unwell when reported

10 31%

Died

3 9.4%

Euthanised

5 16%

Not known

9 28%

Problems reported at the same time

16 50%

14 44%

14 44%

12 38%

11 34%

10 31%

10 31%

9 28%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause eosinophilia in dogs?: 32 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 12 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eosinophilia with similar medicines

Eosinophilia after Doxycycline 32 reports · 0.8% of its reports
Eosinophilia after Metronidazole 22 reports · 0.7% of its reports

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with eosinophilia