Weakness after Diphenhydramine in dogs

204 reports to the FDA describe weakness in dogs given Diphenhydramine. That is 4.3% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

204Reports
80%Marked serious
18%Recovered
31%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
91 51%
1–2 days
26 14%
3–7 days
14 7.8%
1–4 weeks
19 11%
Over a month
30 17%

How the animals did

Recovered
35 17%
Recovered with lasting effects
2 1.0%
Still unwell when reported
83 41%
Died
26 13%
Euthanised
37 18%
Not known
21 10%

Problems reported at the same time

Age of the animals

Under 1 year
14
1–3 years
45
4–7 years
36
8–11 years
67
12+ years
42

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause weakness in dogs?
204 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weakness with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with weakness