Tachycardia after Diphenhydramine in dogs

141 reports to the FDA describe tachycardia in dogs given Diphenhydramine. That is 3.0% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

141Reports
90%Marked serious
20%Recovered
33%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
87 67%
1–2 days
13 10%
3–7 days
6 4.6%
1–4 weeks
8 6.2%
Over a month
16 12%

How the animals did

Recovered
28 20%
Still unwell when reported
53 38%
Died
27 19%
Euthanised
20 14%
Not known
13 9.2%

Problems reported at the same time

Age of the animals

Under 1 year
14
1–3 years
43
4–7 years
35
8–11 years
38
12+ years
9

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause tachycardia in dogs?
141 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tachycardia with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with tachycardia