Recumbency after Diphenhydramine in dogs

The FDA has received 46 reports of recumbency in dogs after Diphenhydramine. That is 1.0% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

46Reports
85%Marked serious
24%Recovered
37%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
26 67%
1–2 days
1 2.6%
3–7 days
1 2.6%
1–4 weeks
5 13%
Over a month
6 15%

How the animals did

Recovered
11 24%
Still unwell when reported
13 28%
Died
10 22%
Euthanised
7 15%
Not known
5 11%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
16
4–7 years
12
8–11 years
12
12+ years
5

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause recumbency in dogs?
46 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Recumbency with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with recumbency