Hypotension after Diphenhydramine in dogs

The FDA has received 89 reports of hypotension in dogs after Diphenhydramine. That is 1.9% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

89Reports
94%Marked serious
21%Recovered
27%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
60 75%
1–2 days
9 11%
3–7 days
6 7.5%
1–4 weeks
1 1.3%
Over a month
4 5.0%

How the animals did

Recovered
19 21%
Still unwell when reported
42 47%
Died
12 13%
Euthanised
12 13%
Not known
4 4.5%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
44
4–7 years
19
8–11 years
11
12+ years
9

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause hypotension in dogs?
89 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypotension with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with hypotension