Abnormal radiograph finding after Diphenhydramine in dogs

149 reports to the FDA describe abnormal radiograph finding in dogs given Diphenhydramine. That is 3.2% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported unusually often with this medicine.

149Reports

81%Marked serious

7.4%Recovered

39%Died or euthanised

1 daysTypical onset

How soon it started

Same day

53 41%

1–2 days

21 16%

3–7 days

16 12%

1–4 weeks

17 13%

Over a month

22 17%

How the animals did

Recovered

8 5.4%

Recovered with lasting effects

3 2.0%

Still unwell when reported

68 46%

Died

19 13%

Euthanised

39 26%

Not known

12 8.1%

Problems reported at the same time

70 47%

68 46%

62 42%

60 40%

59 40%

58 39%

45 30%

39 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause abnormal radiograph finding in dogs?: 149 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal radiograph finding with similar medicines

Abnormal radiograph finding after Melarsomine (Immiticide) 344 reports · 1.5% of its reports
Abnormal radiograph finding after Polysulfated Glycosaminoglycan 155 reports · 2.8% of its reports
Abnormal radiograph finding after Butorphanol 138 reports · 3.1% of its reports
Abnormal radiograph finding after Cefpodoxime 120 reports · 3.0% of its reports
Abnormal radiograph finding after Tramadol 201 reports · 5.3% of its reports
Abnormal radiograph finding after Florfenicol + Mometasone + Terbinafine 31 reports · 0.9% of its reports
Abnormal radiograph finding after Desoxycorticosterone Pivalate 49 reports · 1.5% of its reports
Abnormal radiograph finding after Propofol 75 reports · 2.4% of its reports
Abnormal radiograph finding after Dirlotapide 28 reports · 1.0% of its reports
Abnormal radiograph finding after Isoflurane 96 reports · 3.5% of its reports

All reported side effects of Diphenhydramine in dogs · Medicines most reported with abnormal radiograph finding