Liver problems after Chondroitin + Glucosamine in dogs

The FDA has received 374 reports of liver problems in dogs after Chondroitin + Glucosamine. That is 14% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

374Reports

60%Marked serious

9.6%Recovered

22%Died or euthanised

35 daysTypical onset

How soon it started

Same day

19 7.5%

1–2 days

22 8.7%

3–7 days

21 8.3%

1–4 weeks

53 21%

Over a month

137 54%

How the animals did

Recovered

30 8.0%

Recovered with lasting effects

6 1.6%

Still unwell when reported

188 50%

Died

27 7.2%

Euthanised

54 14%

Not known

69 18%

Problems reported at the same time

156 42%

140 37%

122 33%

91 24%

80 21%

58 16%

54 14%

Elevated gamma-glutamyl transferase (ggt)

50 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

177

12+ years

130

About this medicine

Type: medicine.

Questions owners ask

Can Chondroitin + Glucosamine cause liver problems in dogs?: 374 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 35 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Melarsomine (Immiticide) 1,315 reports · 5.8% of its reports
Liver problems after Polysulfated Glycosaminoglycan 548 reports · 10% of its reports
Liver problems after Diphenhydramine 500 reports · 11% of its reports
Liver problems after Butorphanol 371 reports · 8.4% of its reports
Liver problems after Cefpodoxime 475 reports · 12% of its reports
Liver problems after Tramadol 684 reports · 18% of its reports
Liver problems after Florfenicol + Mometasone + Terbinafine 133 reports · 3.8% of its reports
Liver problems after Desoxycorticosterone Pivalate 276 reports · 8.3% of its reports
Liver problems after Propofol 201 reports · 6.5% of its reports
Liver problems after Dirlotapide 284 reports · 10% of its reports

All reported side effects of Chondroitin + Glucosamine in dogs · Medicines most reported with liver problems