Liver problems after Atipamezole in dogs

The FDA has received 182 reports of liver problems in dogs after Atipamezole. That is 6.9% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

182Reports
52%Marked serious
8.2%Recovered
32%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
32 30%
1–2 days
26 24%
3–7 days
13 12%
1–4 weeks
18 17%
Over a month
19 18%

How the animals did

Recovered
15 8.2%
Still unwell when reported
44 24%
Died
32 18%
Euthanised
27 15%
Not known
64 35%

Problems reported at the same time

Age of the animals

Under 1 year
14
1–3 years
36
4–7 years
60
8–11 years
49
12+ years
19

About this medicine

Type: medicine.

Questions owners ask

Can Atipamezole cause liver problems in dogs?
182 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Atipamezole in dogs · Medicines most reported with liver problems