Liver problems after Amlodipine in dogs

The FDA has received 52 reports of liver problems in dogs after Amlodipine. That is 14% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

52Reports
75%Marked serious
5.8%Recovered
33%Died or euthanised
96 daysTypical onset
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How soon it started

Same day
3 7.9%
1–2 days
3 7.9%
3–7 days
1 2.6%
1–4 weeks
4 11%
Over a month
27 71%

How the animals did

Recovered
2 3.8%
Recovered with lasting effects
1 1.9%
Still unwell when reported
10 19%
Died
4 7.7%
Euthanised
13 25%
Not known
22 42%

Problems reported at the same time

22 42%
17 33%
16 31%
Elevated gamma-glutamyl transferase (ggt)
14 27%

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
5
8–11 years
21
12+ years
25

About this medicine

Type: medicine.

Questions owners ask

Can Amlodipine cause liver problems in dogs?
52 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 96 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Amlodipine in dogs · Medicines most reported with liver problems