Liver problems after Amantadine in dogs

62 reports to the FDA describe liver problems in dogs given Amantadine. That is 12% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

62Reports
74%Marked serious
6.5%Recovered
32%Died or euthanised
37 daysTypical onset
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How soon it started

Same day
3 6.4%
1–2 days
2 4.3%
3–7 days
5 11%
1–4 weeks
11 23%
Over a month
26 55%

How the animals did

Recovered
4 6.5%
Still unwell when reported
31 50%
Died
8 13%
Euthanised
12 19%
Not known
7 11%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
7
8–11 years
23
12+ years
32

About this medicine

Type: medicine.

Questions owners ask

Can Amantadine cause liver problems in dogs?
62 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 37 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Amantadine in dogs · Medicines most reported with liver problems