Liver problems after Acetylsalicylic Acid in dogs

The FDA has received 53 reports of liver problems in dogs after Acetylsalicylic Acid. That is 34% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

53Reports

47%Marked serious

3.8%Recovered

34%Died or euthanised

6 daysTypical onset

How soon it started

Same day

3 6.4%

1–2 days

8 17%

3–7 days

13 28%

1–4 weeks

17 36%

Over a month

6 13%

How the animals did

Recovered

2 3.8%

Still unwell when reported

32 60%

Died

8 15%

Euthanised

10 19%

Not known

1 1.9%

Problems reported at the same time

33 62%

29 55%

25 47%

18 34%

13 25%

13 25%

12 23%

10 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Acetylsalicylic Acid cause liver problems in dogs?: 53 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Melarsomine (Immiticide) 1,315 reports · 5.8% of its reports
Liver problems after Polysulfated Glycosaminoglycan 548 reports · 10% of its reports
Liver problems after Diphenhydramine 500 reports · 11% of its reports
Liver problems after Butorphanol 371 reports · 8.4% of its reports
Liver problems after Cefpodoxime 475 reports · 12% of its reports
Liver problems after Tramadol 684 reports · 18% of its reports
Liver problems after Florfenicol + Mometasone + Terbinafine 133 reports · 3.8% of its reports
Liver problems after Desoxycorticosterone Pivalate 276 reports · 8.3% of its reports
Liver problems after Propofol 201 reports · 6.5% of its reports
Liver problems after Dirlotapide 284 reports · 10% of its reports

All reported side effects of Acetylsalicylic Acid in dogs · Medicines most reported with liver problems