Restlessness or agitation after Sarolaner + Selamectin (Revolution Plus) in cats

162 reports to the FDA describe restlessness or agitation in cats given Sarolaner + Selamectin. That is 2.0% of all reports for this medicine, compared with 4.9% across reports for all cat medicines, so it is reported less often than average with this medicine.

162Reports

33%Marked serious

31%Recovered

1.9%Died or euthanised

Same dayTypical onset

How soon it started

Same day

110 70%

1–2 days

30 19%

3–7 days

6 3.8%

1–4 weeks

10 6.3%

Over a month

2 1.3%

How the animals did

Recovered

51 31%

Still unwell when reported

55 34%

Died

2 1.2%

Euthanised

1 0.6%

Not known

53 33%

Problems reported at the same time

65 40%

39 24%

27 17%

25 15%

24 15%

Application site reaction

23 14%

Vocalising

19 12%

Hair loss

19 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly. Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this combination include Revolution Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner + Selamectin cause restlessness or agitation in cats?: 162 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Fluralaner (Bravecto) 346 reports · 3.3% of its reports
Restlessness or agitation after Fluralaner + Moxidectin (Bravecto Plus) 107 reports · 3.3% of its reports
Restlessness or agitation after Lotilaner (Credelio) 95 reports · 11% of its reports

All reported side effects of Sarolaner + Selamectin in cats · Medicines most reported with restlessness or agitation