Hair loss after Sarolaner + Selamectin (Revolution Plus) in cats

The FDA has received 3,362 reports of hair loss in cats after Sarolaner + Selamectin. That is 41% of all reports for this medicine, compared with 14% across reports for all cat medicines, so it is reported unusually often with this medicine.

3,362Reports
24%Marked serious
7.7%Recovered
0.7%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
992 31%
1–2 days
1,243 38%
3–7 days
589 18%
1–4 weeks
288 8.9%
Over a month
122 3.8%

How the animals did

Recovered
257 7.6%
Recovered with lasting effects
3 0.1%
Still unwell when reported
1,778 53%
Died
11 0.3%
Euthanised
13 0.4%
Not known
1,300 39%

Problems reported at the same time

Age of the animals

Under 1 year
194
1–3 years
995
4–7 years
929
8–11 years
604
12+ years
323

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly. Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this combination include Revolution Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner + Selamectin cause hair loss in cats?
3,362 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hair loss with similar medicines

All reported side effects of Sarolaner + Selamectin in cats · Medicines most reported with hair loss