Sarolaner + Selamectin (Revolution Plus) side effects in cats
8,227 reports sent to the FDA between 2019 and 2026 involve Sarolaner + Selamectin in cats. The most reported problems were hair loss, application site reaction, itching. 33% were marked serious, and where it was recorded, signs eased after stopping the medicine in 13% of cases.
About this medicine
Sarolaner kills fleas, ticks and some mites; monthly. Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).
Products with this combination include Revolution Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a cat still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (7,641 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Domestic Shorthair 4,726 reports
- Cat (other) 1,346 reports
- Domestic Longhair 498 reports
- Domestic Mediumhair 452 reports
- Maine Coon 121 reports
- American Curl Shorthair 111 reports
- Siamese 99 reports
- Ragdoll 79 reports
- Persian 54 reports
- Bengal 49 reports