Breathing problems after Sarolaner + Selamectin (Revolution Plus) in cats

208 reports to the FDA describe breathing problems in cats given Sarolaner + Selamectin. That is 2.5% of all reports for this medicine, compared with 4.7% across reports for all cat medicines, so it is reported less often than average with this medicine.

208Reports

74%Marked serious

25%Recovered

12%Died or euthanised

Same dayTypical onset

How soon it started

Same day

115 59%

1–2 days

53 27%

3–7 days

13 6.6%

1–4 weeks

12 6.1%

Over a month

3 1.5%

How the animals did

Recovered

51 25%

Still unwell when reported

81 39%

Died

11 5.3%

Euthanised

13 6.3%

Not known

52 25%

Problems reported at the same time

67 32%

54 26%

48 23%

37 18%

Restlessness or agitation

27 13%

Fever

26 13%

Death

24 12%

Wobbliness (ataxia)

23 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly. Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this combination include Revolution Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner + Selamectin cause breathing problems in cats?: 208 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

Breathing problems after Fluralaner (Bravecto) 277 reports · 2.6% of its reports
Breathing problems after Fluralaner + Moxidectin (Bravecto Plus) 103 reports · 3.2% of its reports
Breathing problems after Lotilaner (Credelio) 173 reports · 19% of its reports
Breathing problems after Sarolaner (Simparica) 27 reports · 11% of its reports

All reported side effects of Sarolaner + Selamectin in cats · Medicines most reported with breathing problems