Itching after Sarolaner + Selamectin (Revolution Plus) in cats

1,034 reports to the FDA describe itching in cats given Sarolaner + Selamectin. That is 13% of all reports for this medicine, compared with 8.9% across reports for all cat medicines.

1,034Reports
39%Marked serious
15%Recovered
0.9%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
411 41%
1–2 days
296 30%
3–7 days
133 13%
1–4 weeks
88 8.9%
Over a month
64 6.5%

How the animals did

Recovered
160 15%
Still unwell when reported
569 55%
Died
1 0.1%
Euthanised
8 0.8%
Not known
296 29%

Problems reported at the same time

Age of the animals

Under 1 year
93
1–3 years
310
4–7 years
233
8–11 years
188
12+ years
118

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly. Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this combination include Revolution Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner + Selamectin cause itching in cats?
1,034 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Itching with similar medicines

All reported side effects of Sarolaner + Selamectin in cats · Medicines most reported with itching