Itching after Lotilaner (Credelio) in cats

205 reports to the FDA describe itching in cats given Lotilaner. That is 23% of all reports for this medicine, compared with 8.9% across reports for all cat medicines, so it is reported unusually often with this medicine.

205Reports
12%Marked serious
21%Recovered
1.0%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
100 52%
1–2 days
22 11%
3–7 days
5 2.6%
1–4 weeks
29 15%
Over a month
36 19%

How the animals did

Recovered
44 21%
Still unwell when reported
82 40%
Died
2 1.0%
Not known
77 38%

Problems reported at the same time

Age of the animals

Under 1 year
27
1–3 years
60
4–7 years
40
8–11 years
38
12+ years
25

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause itching in cats?
205 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Itching with similar medicines

All reported side effects of Lotilaner in cats · Medicines most reported with itching