Excessive chewing, licking and/or grooming after Lotilaner (Credelio) in cats

30 reports to the FDA describe excessive chewing, licking and/or grooming in cats given Lotilaner. That is 3.3% of all reports for this medicine, compared with 0.4% across reports for all cat medicines, so it is reported unusually often with this medicine.

30Reports

10%Marked serious

27%Recovered

0.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

23 77%

1–2 days

2 6.7%

3–7 days

1 3.3%

1–4 weeks

3 10%

Over a month

1 3.3%

How the animals did

Recovered

8 27%

Still unwell when reported

10 33%

Not known

12 40%

Problems reported at the same time

Breathing problems

17 57%

Itching

15 50%

Restlessness or agitation

10 33%

Behaviour change

7 23%

Pacing

3 10%

Lethargy

3 10%

Vocalising

2 6.7%

Drooling

2 6.7%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause excessive chewing, licking and/or grooming in cats?: 30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive chewing, licking and/or grooming with similar medicines

Excessive chewing, licking and/or grooming after Fluralaner (Bravecto) 42 reports · 0.4% of its reports
Excessive chewing, licking and/or grooming after Sarolaner + Selamectin (Revolution Plus) 46 reports · 0.6% of its reports
Excessive chewing, licking and/or grooming after Fluralaner + Moxidectin (Bravecto Plus) 31 reports · 1.0% of its reports

All reported side effects of Lotilaner in cats · Medicines most reported with excessive chewing, licking and/or grooming