Itching after Fluralaner + Moxidectin (Bravecto Plus) in cats

The FDA has received 404 reports of itching in cats after Fluralaner + Moxidectin. That is 12% of all reports for this medicine, compared with 8.9% across reports for all cat medicines.

404Reports
50%Marked serious
18%Recovered
2.0%Died or euthanised
1 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
147 48%
1–2 days
87 28%
3–7 days
27 8.8%
1–4 weeks
20 6.5%
Over a month
25 8.2%

How the animals did

Recovered
71 18%
Recovered with lasting effects
1 0.2%
Still unwell when reported
302 75%
Died
4 1.0%
Euthanised
4 1.0%
Not known
22 5.4%

Problems reported at the same time

Age of the animals

Under 1 year
33
1–3 years
115
4–7 years
108
8–11 years
81
12+ years
54

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Bravecto Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner + Moxidectin cause itching in cats?
404 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Itching with similar medicines

All reported side effects of Fluralaner + Moxidectin in cats · Medicines most reported with itching