Vomiting after Fluralaner + Moxidectin (Bravecto Plus) in cats

340 reports to the FDA describe vomiting in cats given Fluralaner + Moxidectin. That is 10% of all reports for this medicine, compared with 18% across reports for all cat medicines, so it is reported less often than average with this medicine.

340Reports

50%Marked serious

31%Recovered

6.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

144 56%

1–2 days

68 26%

3–7 days

22 8.6%

1–4 weeks

3 1.2%

Over a month

20 7.8%

How the animals did

Recovered

106 31%

Still unwell when reported

191 56%

Died

10 2.9%

Euthanised

11 3.2%

Not known

22 6.5%

Problems reported at the same time

103 30%

102 30%

52 15%

52 15%

38 11%

Application site reaction

36 11%

Itching

35 10%

Behaviour change

25 7.4%

Age of the animals

Under 1 year

1–3 years

102

4–7 years

8–11 years

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Bravecto Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner + Moxidectin cause vomiting in cats?: 340 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Fluralaner (Bravecto) 1,019 reports · 9.6% of its reports
Vomiting after Sarolaner + Selamectin (Revolution Plus) 729 reports · 8.9% of its reports
Vomiting after Lotilaner (Credelio) 186 reports · 21% of its reports
Vomiting after Sarolaner (Simparica) 78 reports · 31% of its reports

All reported side effects of Fluralaner + Moxidectin in cats · Medicines most reported with vomiting