Vomiting after Lotilaner (Credelio) in cats

The FDA has received 186 reports of vomiting in cats after Lotilaner. That is 21% of all reports for this medicine, compared with 18% across reports for all cat medicines.

186Reports
15%Marked serious
51%Recovered
3.8%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
102 57%
1–2 days
30 17%
3–7 days
6 3.3%
1–4 weeks
16 8.9%
Over a month
26 14%

How the animals did

Recovered
93 50%
Recovered with lasting effects
1 0.5%
Still unwell when reported
45 24%
Died
6 3.2%
Euthanised
1 0.5%
Not known
40 22%

Problems reported at the same time

Age of the animals

Under 1 year
32
1–3 years
43
4–7 years
37
8–11 years
21
12+ years
33

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause vomiting in cats?
186 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

All reported side effects of Lotilaner in cats · Medicines most reported with vomiting