Diarrhea after Lotilaner (Credelio) in cats

The FDA has received 44 reports of diarrhea in cats after Lotilaner. That is 4.9% of all reports for this medicine, compared with 5.1% across reports for all cat medicines.

44Reports
39%Marked serious
32%Recovered
2.3%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
14 32%
1–2 days
13 30%
3–7 days
4 9.1%
1–4 weeks
6 14%
Over a month
7 16%

How the animals did

Recovered
14 32%
Still unwell when reported
22 50%
Died
1 2.3%
Not known
7 16%

Problems reported at the same time

26 59%
10 23%
5 11%
Hyperglycaemia
4 9.1%
3 6.8%

Age of the animals

Under 1 year
16
1–3 years
13
4–7 years
3
8–11 years
7
12+ years
3

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause diarrhea in cats?
44 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

All reported side effects of Lotilaner in cats · Medicines most reported with diarrhea