Diarrhea after Sarolaner + Selamectin (Revolution Plus) in cats

282 reports to the FDA describe diarrhea in cats given Sarolaner + Selamectin. That is 3.4% of all reports for this medicine, compared with 5.1% across reports for all cat medicines.

282Reports
43%Marked serious
22%Recovered
6.4%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
124 45%
1–2 days
97 35%
3–7 days
28 10%
1–4 weeks
16 5.8%
Over a month
10 3.6%

How the animals did

Recovered
62 22%
Still unwell when reported
125 44%
Died
10 3.5%
Euthanised
8 2.8%
Not known
77 27%

Problems reported at the same time

Age of the animals

Under 1 year
65
1–3 years
69
4–7 years
45
8–11 years
41
12+ years
49

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly. Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this combination include Revolution Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner + Selamectin cause diarrhea in cats?
282 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

All reported side effects of Sarolaner + Selamectin in cats · Medicines most reported with diarrhea