Loss of appetite after Fluralaner + Moxidectin (Bravecto Plus) in cats

The FDA has received 272 reports of loss of appetite in cats after Fluralaner + Moxidectin. That is 8.4% of all reports for this medicine, compared with 14% across reports for all cat medicines, so it is reported less often than average with this medicine.

272Reports
68%Marked serious
18%Recovered
9.9%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
101 48%
1–2 days
56 27%
3–7 days
21 10%
1–4 weeks
13 6.2%
Over a month
19 9.0%

How the animals did

Recovered
47 17%
Recovered with lasting effects
2 0.7%
Still unwell when reported
179 66%
Died
8 2.9%
Euthanised
19 7.0%
Not known
17 6.3%

Problems reported at the same time

155 57%
102 38%
39 14%
35 13%
30 11%

Age of the animals

Under 1 year
18
1–3 years
78
4–7 years
63
8–11 years
61
12+ years
44

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Bravecto Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner + Moxidectin cause loss of appetite in cats?
272 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Fluralaner + Moxidectin in cats · Medicines most reported with loss of appetite