Skin rash or irritation after Sarolaner + Selamectin (Revolution Plus) in cats

167 reports to the FDA describe skin rash or irritation in cats given Sarolaner + Selamectin. That is 2.0% of all reports for this medicine, compared with 2.0% across reports for all cat medicines.

167Reports
54%Marked serious
8.4%Recovered
3.6%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
36 23%
1–2 days
41 26%
3–7 days
29 19%
1–4 weeks
32 21%
Over a month
17 11%

How the animals did

Recovered
14 8.4%
Still unwell when reported
119 71%
Died
3 1.8%
Euthanised
3 1.8%
Not known
28 17%

Problems reported at the same time

Age of the animals

Under 1 year
13
1–3 years
43
4–7 years
25
8–11 years
35
12+ years
40

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly. Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this combination include Revolution Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner + Selamectin cause skin rash or irritation in cats?
167 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin rash or irritation with similar medicines

All reported side effects of Sarolaner + Selamectin in cats · Medicines most reported with skin rash or irritation