Breathing problems after Sarolaner (Simparica) in cats

The FDA has received 27 reports of breathing problems in cats after Sarolaner. That is 11% of all reports for this medicine, compared with 4.7% across reports for all cat medicines, so it is reported unusually often with this medicine.

27Reports
67%Marked serious
11%Recovered
3.7%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
22 81%
1–2 days
3 11%
3–7 days
1 3.7%
1–4 weeks
1 3.7%
Over a month
0 0.0%

How the animals did

Recovered
3 11%
Still unwell when reported
19 70%
Euthanised
1 3.7%
Not known
4 15%

Problems reported at the same time

13 48%
6 22%
Vocalising
6 22%
6 22%
Hyperaesthesia
4 15%

Age of the animals

Under 1 year
3
1–3 years
4
4–7 years
8
8–11 years
3
12+ years
4

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause breathing problems in cats?
27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

All reported side effects of Sarolaner in cats · Medicines most reported with breathing problems