Sarolaner (Simparica) side effects in cats

255 reports sent to the FDA between 2016 and 2026 involve Sarolaner in cats. The most reported problems were seizures, accidental exposure, vomiting. 58% were marked serious.

255Reports
58%Marked serious
82%Only medicine involved
15%Recovered
2.0%Died or euthanised
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About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Most reported side effects

105 41%
78 31%
69 27%
53 21%
43 17%
26 10%
Behaviour change
16 6.3%
Wobbliness (ataxia)
16 6.3%
Diarrhea
14 5.5%
Dilated pupils
13 5.1%
Foaming at the mouth
12 4.7%
Hiding
11 4.3%

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a cat still getting fleas or heartworm), not about a side effect.

Didn't stop worms
3 1.2%
Didn't work as expected
1 0.4%

How soon problems started

Same day
182 73%
1–2 days
55 22%
3–7 days
4 1.6%
1–4 weeks
4 1.6%
Over a month
4 1.6%

Time from the first dose to the first sign, where both dates were reported (249 reports).

How the animals did

Recovered
37 15%
Still unwell when reported
173 68%
Died
2 0.8%
Euthanised
3 1.2%
Not known
40 16%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other isoxazoline flea and tick medicines for cats