Restlessness or agitation after Fluralaner (Bravecto) in cats

The FDA has received 346 reports of restlessness or agitation in cats after Fluralaner. That is 3.3% of all reports for this medicine, compared with 4.9% across reports for all cat medicines, so it is reported less often than average with this medicine.

346Reports
56%Marked serious
45%Recovered
1.7%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
273 88%
1–2 days
24 7.7%
3–7 days
5 1.6%
1–4 weeks
5 1.6%
Over a month
4 1.3%

How the animals did

Recovered
154 45%
Still unwell when reported
164 47%
Died
4 1.2%
Euthanised
2 0.6%
Not known
22 6.4%

Problems reported at the same time

Age of the animals

Under 1 year
30
1–3 years
113
4–7 years
89
8–11 years
64
12+ years
41

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause restlessness or agitation in cats?
346 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

All reported side effects of Fluralaner in cats · Medicines most reported with restlessness or agitation