Application site reaction after Fluralaner (Bravecto) in cats

1,853 reports to the FDA describe application site reaction in cats given Fluralaner. That is 17% of all reports for this medicine, compared with 8.1% across reports for all cat medicines, so it is reported unusually often with this medicine.

1,853Reports
59%Marked serious
16%Recovered
1.2%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
568 43%
1–2 days
354 27%
3–7 days
216 16%
1–4 weeks
87 6.6%
Over a month
97 7.3%

How the animals did

Recovered
302 16%
Recovered with lasting effects
2 0.1%
Still unwell when reported
1,372 74%
Died
7 0.4%
Euthanised
16 0.9%
Not known
154 8.3%

Problems reported at the same time

Age of the animals

Under 1 year
89
1–3 years
460
4–7 years
507
8–11 years
414
12+ years
244

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause application site reaction in cats?
1,853 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Application site reaction with similar medicines

All reported side effects of Fluralaner in cats · Medicines most reported with application site reaction