Vocalising after Sarolaner + Selamectin (Revolution Plus) in cats

The FDA has received 159 reports of vocalising in cats after Sarolaner + Selamectin. That is 1.9% of all reports for this medicine, compared with 3.1% across reports for all cat medicines, so it is reported less often than average with this medicine.

159Reports
51%Marked serious
21%Recovered
11%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
82 55%
1–2 days
40 27%
3–7 days
8 5.4%
1–4 weeks
11 7.4%
Over a month
8 5.4%

How the animals did

Recovered
33 21%
Still unwell when reported
63 40%
Died
9 5.7%
Euthanised
8 5.0%
Not known
46 29%

Problems reported at the same time

Age of the animals

Under 1 year
21
1–3 years
37
4–7 years
30
8–11 years
29
12+ years
29

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly. Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this combination include Revolution Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner + Selamectin cause vocalising in cats?
159 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

All reported side effects of Sarolaner + Selamectin in cats · Medicines most reported with vocalising