Lethargy after Eprinomectin + Praziquantel in cats

96 reports to the FDA describe lethargy in cats given Eprinomectin + Praziquantel. That is 16% of all reports for this medicine, compared with 14% across reports for all cat medicines.

96Reports
24%Marked serious
29%Recovered
8.3%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
44 46%
1–2 days
37 39%
3–7 days
8 8.4%
1–4 weeks
4 4.2%
Over a month
2 2.1%

How the animals did

Recovered
28 29%
Still unwell when reported
8 8.3%
Died
3 3.1%
Euthanised
5 5.2%
Not known
52 54%

Problems reported at the same time

19 20%
15 16%
Fever
13 14%
10 10%
Not drinking
9 9.4%

Age of the animals

Under 1 year
31
1–3 years
23
4–7 years
17
8–11 years
7
12+ years
12

About this medicine

Eprinomectin controls worms and prevents heartworm. Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Eprinomectin + Praziquantel cause lethargy in cats?
96 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Eprinomectin + Praziquantel in cats · Medicines most reported with lethargy