Tremors after Eprinomectin + Praziquantel in cats

28 reports to the FDA describe tremors in cats given Eprinomectin + Praziquantel. That is 4.8% of all reports for this medicine, compared with 2.6% across reports for all cat medicines, so it is reported unusually often with this medicine.

28Reports
43%Marked serious
39%Recovered
14%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
14 50%
1–2 days
12 43%
3–7 days
2 7.1%
1–4 weeks
0 0.0%
Over a month
0 0.0%

How the animals did

Recovered
11 39%
Still unwell when reported
2 7.1%
Died
3 11%
Euthanised
1 3.6%
Not known
11 39%

Problems reported at the same time

10 36%
Disorientation
7 25%
Seizures
5 18%
Breathing problems
5 18%
4 14%

Age of the animals

Under 1 year
13
1–3 years
7
4–7 years
5
8–11 years
2
12+ years
1

About this medicine

Eprinomectin controls worms and prevents heartworm. Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Eprinomectin + Praziquantel cause tremors in cats?
28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tremors with similar medicines

All reported side effects of Eprinomectin + Praziquantel in cats · Medicines most reported with tremors